BIBW 2992

Mfr.No.	SIH-496
Alternative Names	Afatinib, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Appearance	Crystalline solid
Function	EGFR, HER2 kinase inhibitor
Inchi	InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
Inchikey	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Mode Of Action	Inhibitor
Molecular Formula	C24H25ClFN5O3
Pubchem Cid	10184653
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute Toxicity: Oral, Category 2 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300: Fatal if swallowed. H315: Causes skin irritation. H318: Causes serious eye damage. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage through prolonged or repeated exposure. Precautionary statements: P264: Wash {hands} thoroughly after handling. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P302+352: IF ON SKIN: Wash with plenty of soap and water. P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.
Smiles	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	850140-72-6
Molecular Weight	485.9
Scientific Background	BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.
Solubility	Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	>99%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900279-1	SIH-496-5MG	5 mg	$168		Add to Cart
BHB11900279-2	SIH-496-25MG	25 mg	$561		Add to Cart

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