Axitinib

Mfr.No.	SIH-494
Alternative Names	AG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide
Appearance	White to tan powder
Function	VEGFR kinase inhibitor
Inchi	InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
Inchikey	RITAVMQDGBJQJZ-FMIVXFBMSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H18N4OS
Pubchem Cid	6450551
Sd File	C22H18N4OS APtclcactv07301413312D 0 0.00000 0.00000 46 49 0 0 0 0 0 0 0 0999 V2000 6.8671 -1.6565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 0.3435 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -0.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 -0.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -1.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 0.3435 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -0.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6113 2.9998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5683 3.4122 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9220 3.9503 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9005 4.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -4.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8719 -2.0506 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -2.8465 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6793 0.1482 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0010 -1.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 -1.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 -1.6565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2791 2.2555 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2690 -3.1565 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 -2.6565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9900 1.0987 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9685 1.3050 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -3.1565 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2629 -0.6565 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1350 -1.6565 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 -0.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7331 -1.1565 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2576 2.4617 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.6793 -1.4612 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 -2.2765 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 0.9635 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.1535 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5759 1.5602 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8059 0.1535 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -1.4665 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3825 0.8435 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4030 0.9635 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.1535 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0046 2.8719 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1750 3.5401 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5079 4.4118 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9169 -4.1565 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 -4.7765 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1569 -4.1565 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0931 4.7458 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16 26 1 0 0 0 0 17 26 1 0 0 0 0 20 21 2 0 0 0 0 25 30 1 0 0 0 0 28 30 1 0 0 0 0 15 25 2 0 0 0 0 21 24 1 0 0 0 0 12 24 1 0 0 0 0 19 29 1 0 0 0 0 9 29 2 0 0 0 0 27 28 2 0 0 0 0 15 27 1 0 0 0 0 2 27 1 0 0 0 0 1 28 1 0 0 0 0 15 22 1 0 0 0 0 1 16 2 0 0 0 0 3 16 1 0 0 0 0 2 3 2 0 0 0 0 17 18 1 0 0 0 0 4 17 2 0 0 0 0 18 21 1 0 0 0 0 5 18 2 0 0 0 0 22 23 2 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 19 23 1 0 0 0 0 6 7 2 0 0 0 0 8 19 2 0 0 0 0 8 10 1 0 0 0 0 9 11 1 0 0 0 0 10 11 2 0 0 0 0 13 30 1 0 0 0 0 14 24 1 0 0 0 0 1 31 1 0 0 0 0 2 32 1 0 0 0 0 3 33 1 0 0 0 0 22 34 1 0 0 0 0 4 35 1 0 0 0 0 5 36 1 0 0 0 0 23 37 1 0 0 0 0 6 38 1 0 0 0 0 7 39 1 0 0 0 0 8 40 1 0 0 0 0 9 41 1 0 0 0 0 10 42 1 0 0 0 0 12 43 1 0 0 0 0 12 44 1 0 0 0 0 12 45 1 0 0 0 0 11 46 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cardiovascular System ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H410 Very toxic to aquatic life with long lasting effects Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P330 Rinse mouth. P391 Collect spillage. P501 Dispose of contents/ container to an approved waste disposal plant.
Smiles	CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	319460-85-0
Molecular Weight	386.5
Scientific Background	Axitinib is a potent and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. It has also been shown to inhibit PDGFR-β and c-Kit.
Solubility	Soluble to 25 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Hu-Lowe D.D., et al. (2008) Clin. Cancer Res: J. Am. Ass. Cancer Res. 14(22): 7272–7283.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900277-1	SIH-494-10MG	10 mg	$224		Add to Cart

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