ARN-6039 is an orally available inverse agonist of RORgamma for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORgamma was demonstrated in a RORgamma-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 release from CD4+T cell assays (220 nM).