Amiodarone Hydrochloride

Mfr.No.	SIH-393
Alternative Names	2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Appearance	White solid
Function	Autophagy inducer
Inchi	InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
Inchikey	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Mode Of Action	Inducer
Molecular Formula	C25H29I2NO3•HCl
Pubchem Cid	441325
Sd File	C25H30ClI2NO3 APtclcactv04251417312D 0 0.00000 0.00000 62 62 0 0 0 0 0 0 0 0999 V2000 0.0000 4.8035 0.0000 H 0 3 0 0 0 0 0 0 0 0 0 0 4.4015 4.1350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1708 4.3522 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8136 6.0470 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4015 2.1350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5355 3.6350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5355 2.6350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7974 3.1350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2974 2.2690 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7491 6.6657 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7974 1.4030 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7276 6.8719 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0168 8.0286 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3704 8.5667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2974 0.5369 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3275 8.9791 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6811 9.5172 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2138 3.9397 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7974 3.1350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5029 5.0965 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4600 5.5089 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1493 4.5584 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7921 6.2532 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8566 5.6346 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5244 4.8903 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4385 5.7151 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.0383 7.8224 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2676 3.6350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2676 2.6350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8171 3.8141 0.0000 I 0 0 0 0 0 0 0 0 0 0 0 0 9.1028 7.2037 0.0000 I 0 0 0 0 0 0 0 0 0 0 0 0 6.2138 2.3303 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0000 4.8035 0.0000 Cl 0 5 0 0 0 0 0 0 0 0 0 0 4.4015 4.7550 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9782 3.7629 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3995 6.5085 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4015 1.5150 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3800 3.3471 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6897 3.7456 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9986 3.9450 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9986 2.3250 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7723 1.8705 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7723 2.6675 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7286 7.2853 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1353 6.7530 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3224 1.8015 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3224 1.0044 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7482 6.2522 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3414 6.7845 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7604 0.2269 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6074 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8343 0.8469 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0374 7.4090 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6306 7.9413 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8235 8.8587 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9879 8.0788 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9168 8.7865 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5201 9.5685 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7381 9.1717 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2704 9.3246 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8737 10.1065 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0918 9.7098 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 22 30 1 0 0 0 0 23 31 1 0 0 0 0 19 32 1 0 0 0 0 29 32 1 0 0 0 0 24 25 2 0 0 0 0 21 26 1 0 0 0 0 10 26 1 0 0 0 0 12 27 1 0 0 0 0 13 27 1 0 0 0 0 14 27 1 0 0 0 0 18 28 1 0 0 0 0 18 19 2 0 0 0 0 18 25 1 0 0 0 0 28 29 2 0 0 0 0 2 28 1 0 0 0 0 8 19 1 0 0 0 0 20 25 1 0 0 0 0 5 29 1 0 0 0 0 3 20 2 0 0 0 0 4 20 1 0 0 0 0 2 6 2 0 0 0 0 3 22 1 0 0 0 0 4 23 2 0 0 0 0 21 22 2 0 0 0 0 21 23 1 0 0 0 0 5 7 2 0 0 0 0 8 9 1 0 0 0 0 6 7 1 0 0 0 0 9 11 1 0 0 0 0 10 12 1 0 0 0 0 11 15 1 0 0 0 0 13 16 1 0 0 0 0 14 17 1 0 0 0 0 2 34 1 0 0 0 0 3 35 1 0 0 0 0 4 36 1 0 0 0 0 5 37 1 0 0 0 0 8 38 1 0 0 0 0 8 39 1 0 0 0 0 6 40 1 0 0 0 0 7 41 1 0 0 0 0 9 42 1 0 0 0 0 9 43 1 0 0 0 0 10 44 1 0 0 0 0 10 45 1 0 0 0 0 11 46 1 0 0 0 0 11 47 1 0 0 0 0 12 48 1 0 0 0 0 12 49 1 0 0 0 0 15 50 1 0 0 0 0 15 51 1 0 0 0 0 15 52 1 0 0 0 0 13 53 1 0 0 0 0 13 54 1 0 0 0 0 14 55 1 0 0 0 0 14 56 1 0 0 0 0 16 57 1 0 0 0 0 16 58 1 0 0 0 0 16 59 1 0 0 0 0 17 60 1 0 0 0 0 17 61 1 0 0 0 0 17 62 1 0 0 0 0 M CHG 2 1 1 33 -1 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303- May be harmful if swallowed. H312 + H332- Harmful in contact with skin or if inhaled Precautionary statements: P280- Wear protective gloves/ protective clothing.
Smiles	[H+].C1=CC=CC2=C1C(=C(O2)CCCC)C(=O)C3=CC(=C(OCCN(CC)CC)C(=C3)I)I.[Cl-]
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	19774-82-4
Molecular Weight	681.77
Scientific Background	Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
Solubility	Soluble to 50 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	1
Purity	>99 %
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53. 2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900181-1	SIH-393-1G	1 g	$77		Add to Cart

Amiodarone Hydrochloride

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