17-GMB-APA-GA

Mfr.No.	SIH-115
Alternative Names	[(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Appearance	Purple Solid
Function	Hsp90 inhibitor
Inchi	InChI=1S/C39H53N5O11/c1-22-18-26-34(42-16-9-15-41-31(46)12-8-17-44-32(47)13-14-33(44)48)28(45)21-27(36(26)50)43-38(51)23(2)10-7-11-29(53-5)37(55-39(40)52)25(4)20-24(3)35(49)30(19-22)54-6/h7,10-11,13-14,20-22,24,29-30,35,37,42,49H,8-9,12,15-19H2,1-6H3,(H2,40,52)(H,41,46)(H,43,51)/t22-,24+,29+,30+,35-,37+/m1/s1
Inchikey	OPWAYYOLUIAKCJ-DAJJPBRBSA-N
Mode Of Action	Inhibitor
Molecular Formula	C39H53N5O11
Pubchem Cid	57370016
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	O=C/1C2=C(/C(=O)C=C1NC(=O)C(=CC=C[C@H](OC)[C@@H](OC(=O)N)C(=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2)/C)C)NCCCNC(=O)CCCN3C(=O)C=C/C3=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	767.9
Scientific Background	An analog of geldanamycin containing a maleimido moiety suitable for preparation of geldanamycin immunoconjugates (1-3). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Solubility	Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Mandler R., et al. (2004) Cancer Res. 64: 1460. 2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786. 3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900006-1	SIH-115A	1 mg	$226		Add to Cart

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