12(S)-HpETE

Mfr.No.	T37969
Description	12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
Molecular Formula	C20H32O4
Signaling Pathways	Others
Smiles	(CH)(/C=C/C=CC/C=CCCCC(O)=O)(C/C=CCCCCC)OO
Cas Number	71774-10-2
Molecular Weight	336.47
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20427010	T37969	25 ?g	$328	Add to Cart
BHB20427010	T37969	50 ?g	$615	Add to Cart
BHB20427010	T37969	100 ?g	$1160	Add to Cart
BHB20427010	T37969	250 ?g	$2570	Add to Cart