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Home / Biochemicals / Small Molecules

(-)-Cevimeline hydrochloride hemihydrate

SKU : BHB20407275

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Description
Review(s)

Mfr.No.	T13421
Description	Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's syndrome, exhibiting an IC50 value indicative of its affinity for mAChR. This compound's pharmacological effects on the gastrointestinal, urinary, and reproductive systems, alongside its impact on various tissues, were thoroughly examined in species including mice, rats, guinea pigs, rabbits, and dogs. The metabolic breakdown of (-)-SNI-2011 was studied in vitro using rat and dog liver microsomes to assess its biotransformation. Upon oral administration, peak plasma concentrations were reached within an hour in both rats and dogs, showcasing rapid absorption and a subsequent decrease in concentration with a half-life ranging from 0.4 to 1.1 hours. Bioavailability was noted at 50% in rats and 30% in dogs. Metabolic pathways highlighted significant species differences, with both S- and N-oxidized metabolites identified in rats, but only N-oxidized metabolites in dogs. Additionally, gender differences in pharmacokinetics were observed in rats but were absent in dogs. In vitro studies pinpointed the involvement of cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO) in the metabolism of (-)-SNI-2011, specifically through sulfoxidation and N-oxidation processes, respectively. CYP2D and CYP3A were identified as the primary enzymes responsible for sulfoxidation in rat liver microsomes.
Alternative Names	(-)-SNI-2011
Molecular Formula	C10H19ClNO1.5S
Signaling Pathways	Angiogenesis, Tyrosine Kinase/Adaptors
Smiles	C(CH)(SC1)O(C)21CN3CCC2CC3.Cl.(0.5H2O)
Molecular Weight	244.78
Target	ALK

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SKU	Supplier No.	Size	Your price	Quantity
BHB20407275	T13421	25 mg	$3960		Add to Cart

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