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Sirt1-Flox

SKU : BHAM00309

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-190037
Description	Model Description: These mice carry loxP sites flanking exon3 of Sirt1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Sirt1 gene. Official Symbol: Sirt1 NCBI ID: 93759 MGI ID: 2135607 Ensembl ID: ENSMUSG00000020063 Pubmed: Sirt1 Human Ortholog: SIRT1
Nomenclature	C57BL/6JSmoc-Sirt1^{tm1(flox)Smoc}
Exon	Exon 3
Application	Epigenetic
Disease	Fatty Liver Disease
Disease	Cardio-metabolic Disease
KI/KO Gene	Sirt1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Alb1-cre mice.
Synonyms	Sir2, Sir2a, SIR2L1, AA673258, Sir2alpha

Reference	Wang RH, Li C, Deng CX, Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6(7):682-90

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