AAVnerGene AAV Capsid Selection and Evolution Services
Tailored Services for AAV Capsid Assessment and Evolution
AAVnerGene provides a comprehensive suite of services dedicated to the assessment and evolution of AAV capsids, designed to meet the diverse requirements of both in vitro and in vivo research applications.
Capsid Evaluation and Evolution Services
AAV Capsid Library(I) Evaluation: AAVnerGene offers capsid evaluation services utilizing AAV Capsid Library(I). These services are focused on systematically assessing various known AAV capsid serotypes and variants. This evaluation is crucial for researchers looking to determine the most effective AAV capsid types for their specific applications.
AAV Capsid Library(II) Evolution: In addition to evaluation services, AAVnerGene provides capsid evolution services using AAV Capsid Library(II). This service is centered around evolving novel AAV capsid types with specific properties, such as tissue-specific tropism. These advanced services are particularly beneficial for developing new approaches in gene therapy applications.
Diverse Models for AAV Evaluation and Evolution
AAVnerGene offers a range of models to cater to different stages of AAV evaluation and evolution:
In Vitro Models: Includes primary cells and organoids, providing a controlled environment for initial capsid assessment and evolution studies.
In Vivo Models: Comprises animal models such as mice, rats, and non-human primates (NHPs). These models are essential for understanding the behavior of AAV capsids in a living organism and are crucial for preclinical research stages.
Get a Custom Quote
We understand that every research project has unique needs. To accommodate this, AAVnerGene invites researchers and biotech companies to contact us for tailored quotes that suit specific project requirements and objectives in AAV capsid selection and evolution.
For detailed information and to get a custom quote, please reach out to AAVnerGene's dedicated customer service team.
Strategic Workflow for Optimal Capsid Selection
AAVnerGene's tailored capsid selection and evolution workflow is a multi-stage process designed to identify the most promising AAV capsids for specific applications. Our process leverages both in vitro and in vivo models, including primary cell lines, organoids, and animal models such as mice, rats, and non-human primates (NHPs), to ensure comprehensive testing and validation.
Initial Capsid Variety and Screening
The process begins with a diverse array of AAV capsids, categorized under AAV Capsid Library(I). This collection encompasses a wide range of known serotypes and variants, each identified by unique DNA barcodes. The initial library is subjected to a rigorous screening process to identify capsids with the highest potential.
In-Depth Selection Rounds
From this broad spectrum, we narrow down the selection to the top 100,000 capsids. These undergo a second round of more focused evaluation to pinpoint the top 100 capsids that exhibit superior properties for targeted gene delivery.
Final Selection and Collaboration
The final phase involves an individualized capsid test on the top 5 capsids, produced with our proprietary ATHENA I platform. This stage is pivotal as it determines the most efficient capsids tailored to the specific research requirements.
Keywords/Tags
AAV Capsid Library,capsid evaluation,animal models,evolution of AAV capsids