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Home / Proteins & Peptide

RIPK1, GST-Tag

SKU : BHP18200230

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BPS Bioscience

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Mfr.No.	40371
Description	Human RIPK1, also known as RCK and MAP3K19, GenBank Accession No. NM_003804, a.a. 1-327, with N-terminal GST-tag, MW=63 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. Host cell line: Sf9 cells Specific activity: ~4 pmol/min/ug
Background	RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process. TNFalpha is capable of activating the noncanonical NF-kappaB pathway, but this activation of this pathway is negatively regulated by RIPK1.
Immunogen Region	1-327
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_003804
Mw(kda)	63 kDa

Synonyms	RCK, MAP3K19
Uniprot	Q13546

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -70°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 - 0.5%).

Reference	1. Hsu, H. et al., Immunity 4: 387-396, 1996. 2. Kim, J Y. et al., J Cell Sci. 2011 Feb 15;124(Pt 4):647-56.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200230	40371	10 ug	$462		Add to Cart

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