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Home / Primary Antibodies

RIG-I Antibody (DDX58) (F46992)

SKU : BHA17100984

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NSJ Bioreagents

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Mfr.No.	F46992, F46992-0.08ML, F46992-0.4ML
Antigen	DDX58
Clonality	Polyclonal
Description	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I/DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 585-614 from the human protein was used as the immunogen for this DDX58 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	O95786

Format	Purified
Purification	Purified
Storage	Aliquot the DDX58 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Dilution	Western blot: 1:1000

Product Manual	Data Sheet

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17100984-1	F46992-0.08ML	0.08ml	$165		Add to Cart
BHA17100984-2	F46992-0.4ML	0.4ml	$379		Add to Cart

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