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Home / Proteins & Peptide

Recombinant Rat HER2/ErbB2 Protein (Active)

SKU : BHP10305784

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030371
Description	A DNA sequence encoding the rat ErbB2 (AAH61863.1) extracellular domain (Met 4-Thr 656) was expressed and purified, with seven additional amino acids (ALEVLFQ) at the C-terminus.
Alternative Names	ErbB2;Neu;p185erbB2
Reconstitution	Please refer to the printed manual for detailed information.
Background	Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Rat
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	AAH61863.1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	1.Measured by its binding ability in a functional ELISA. 2.Immobilized rat ErbB2 at 10ug/mL (100uL/well) can bind herceptin, the EC50 of herceptin is 30-90ng/mL.
Mol Weight	70.6 kDa
Mw(kda)	70.6 kDa

Sequence Info	Met 4-Thr 656

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 92 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305784	PKSR030371	50ug	$855		Add to Cart

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