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Home / Proteins & Peptide

Recombinant Human CCR4-NOT transcription complex subunit 8(CNOT8)

SKU : BHP10503556

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP871398HU
Alternative Names	CAF1-like protein
Antigen	CNOT8
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Source	E.coli
Abbreviation	CNOT8
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: CCR4-NOT transcription complex subunit 8; Alternative name(s): CAF1-like protein; Short name= CALIFp; CAF2; CCR4-associated factor 8
Expression Region	1-292aa
Mol Weight	60.5kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Nucleus
Uniprot	Q9UFF9, Q9UFF9
Database Links	HGNC:9207 OMIM:603731 KEGG:hsa:9337 STRING:9606.ENSP00000285896 UniGene:Hs.26703
Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Protein Families	CAF1 family
Research Area	Epigenetics and Nuclear Signaling
Weight	59.812kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503556	CSB-EP871398HU	1mg	$1812		Add to Cart
BHP10503556	CSB-EP871398HU	100ug	$419		Add to Cart
BHP10503556	CSB-EP871398HU	20ug	$224		Add to Cart

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