BCL2 is a member of B cell lymphoma 2 (BCL2) family, which are key regulators in intrinsic apoptosis. BCL2 consists of a hydrophobic pocket to which BH3 helixes bind and the binding blocks the apoptosis signal and prevents the cells from death. Increased expression or overexpression under the treatment has been reported in many cancers. Inhibition of BCL2 activity is a promising approach for cancer therapy.
Product Type
Recombinant Proteins
Tag
His
Field of Use
Drug Targets
Molecular Weight
24.7 kDa
Species
Human
Application
ELISA, Western Blot, Inhibitor Screening, Binding Assay.
Expression Source
E. coli
Protein Length
210 aa
Uniprot
P10415
Shipping
Dry Ice
Purity
>95%, SDS-PAGE
Storage
Stable for 12 months at -80°C, Avoid freeze/thaw cycles