Anti-undefined Antibody INSR,2277R Unconjugated BHA10208234

Mfr.No.	3643-RBM2-P1ABX
Alternative Names	CD220 ; HHF5 ; HIR A ; INSR ; Insulin receptor ; Insulin receptor subunit alpha ; IR
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	19p13.2
Clonality	monoclonal
Description	The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular ? subunit and an extracellular ? subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
Host	Rabbit
Immunogen	Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)
Isotype	IgG
Positive Control	Jurkat cells. Human pancreas.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P06213
Gene Id	3643
Clone No	INSR, 2277R
Symbol	INSR
Weight	135kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

1-2μg/ml for 30 minutes at RT

No Description Available.

Have you used this product?

Rate it now..!!

SKU	Supplier No.	Size	Your price	Quantity
BHA10208234	3643-RBM2-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody INSR,2277R Unconjugated BHA10208234

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Anti-undefined Antibody INSR,2277R Unconjugated BHA10208234

Rate it now..!!