Anti-undefined Antibody CFTR,1775R Unconjugated BHA10207901

Mfr.No.	1080-RBM5-P0
Alternative Names	ABC35 ; ATP Binding Cassette Superfamily C Member 7 (ABCC7) ; cAMP-dependent chloride channel ; CFTR ; CFTR/MRP ; Channel conductance-controlling ATPase ; Cystic Fibrosis Transmembrane Conductance Regulator ; MRP7 ; TNR CFTR
Antigen	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Cell Surface
Chromosome Location	7q31.2
Clonality	monoclonal
Conjugate	Unconjugated
Description	Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Host	Rabbit
Immunogen	Recombinant fragment of human CFTR (aa 258-385) (exact sequence is proprietary)
Isotype	IgG
Positive Control	MOLT-4 cells. Pancreas, Kidney or Placenta.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P13569
Gene Id	1080
Clone No	CFTR, 1775R
Symbol	CFTR
Weight	165-170kDa

Buffer	200μg/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200μg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IF, IHC-F

Description

Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IF ; IHC-F

Dilution