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Home / Primary Antibodies / IHC Antibodies

Anti-TWIST1 Antibody BHA11308979

SKU : BHA11308979

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Mfr.No.	LM1040
Alternative Names	Twist-related protein 1 ; Class A basic helix-loop-helix protein 38 ; bHLHa38 ; H-twist ; BHLHA38 ; TWIST
Categories	Primary Antibodies
Chromosome Location	7p21.1
Clonality	monoclonal
Description	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.
Host	Mouse
Immunogen	Purified recombinant fragment of human TWIST1 (AA: 9-74) expressed in E. Coli.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q15672
Uniprot	Q15672
Weight	22 kDa

Description	Product: Mouse IgG1. Specificity: TWIST1 monoclonal antibody detects endogenous levels of TWIST1 protein.
Purity	Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, ICC, FC

Description

WB ; IHC ; ICC ; FC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308979	LM1040	50µl	$314.89		Add to Cart
BHA11308979	LM1040	100µl	$488.40		Add to Cart

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