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Home / Primary Antibodies / Recombinant Antibodies

Anti-IL12RB1 Antibody BHA11307993

SKU : BHA11307993

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Mfr.No.	BS8052
Alternative Names	Interleukin-12 receptor subunit beta-1 ; IL-12 receptor subunit beta-1 ; IL-12R subunit beta-1 ; IL-12R-beta-1 ; IL-12RB1 ; IL-12 receptor beta component ; CD_antigen=CD212 ; IL12RB1 ; IL12R ; IL12RB
Categories	Primary Antibodies
Chromosome Location	19p13.11
Clonality	polyclonal
Description	IL-12, a heterodimeric cytokine composed of two disulfide-bonded glycoprotein subunits, p35 and p40, has pleiotrophic activities including stimulation of the proliferation of activated T and NK cells, induction of IFN-g production by PBMCs, enhancement of the lytic activity of NK/LAK cells and promotion of T-helper (Th) 1 cell responses. The T cell response to IL-12 is mediated through two receptor proteins, designated IL-12Rb-1 and IL-12Rb-2 (4). The genes encoding human IL-12Rb-1 and IL-12Rb-2 map to chromosomes 19p13.1 and 1p31.3-p31.2, respectively. Increased IL-12Rb-2 expression is crucial in regulating Th1 differentiation, whereas IL-12Rb-1 expression is less restricted. Inhibition of IL-12 activity may provide treatment for diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn’s disease, while administration of recombinant IL-12 may aid in the treatment for allergic disorders and asthma.
Host	Rabbit
Immunogen	Recombinant full length Human IL12RB1.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P42701
Uniprot	P42701
Weight	73 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: IL12RB1 polyclonal antibody detects endogenous levels of IL12RB1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11307993	BS8052	50µl	$234.89		Add to Cart
BHA11307993	BS8052	100µl	$368.22		Add to Cart

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