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Home / Primary Antibodies / Recombinant Antibodies

Anti-UGT1A1 Antibody BHA11307947

SKU : BHA11307947

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Mfr.No.	BS7952
Alternative Names	Bilirubin specific UDPGT isozyme 1 ; bilirubin UDP glucuronosyltransferase 1 1 ; bilirubin UDP glucuronosyltransferase isozyme 1 ; Bilirubin-specific UDPGT isozyme 1 ; EC 2.4.1.17 ; GNT1 ; HUG BR1 ; HUG-BR1 ; HUGBR1 ; PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE ; UD11_HUMAN ; UDP glucuronosyltransferase 1 1 [Precursor] ; UDP glucuronosyltransferase 1 family polypeptide A1 ; UDP glucuronosyltransferase 1A1 ; UDP GLYCOSYLTRANSFERASE 1 ; UDP-glucuronosyltransferase 1-1 ; UDP-glucuronosyltransferase 1-A ; UDP-glucuronosyltransferase 1A1 ; UDPGT ; UDPGT 1-1 ; UGT 1A ; UGT-1A ; UGT1 ; UGT1 01 ; UGT1*1 ; UGT1-01 ; UGT1.1 ; UGT1A ; Ugt1a1
Categories	Primary Antibodies
Chromosome Location	2q37.1
Clonality	polyclonal
Description	The human UDP-glucuronosyltransferase 1 (UGT1) locus encodes at least ten UGT1A proteins (UGT1A1-UGT1A10) that play a prominent role in drug and xenobiotic metabolism. Research indicates that nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPAR) can regulate UGTs, which may contribute to the tissue-specific expression pattern of UGTs. Deficiency in the expression and/or activity of UGTs may lead to genetic and acquired diseases such as Crigler-Najjar syndrome and Gilbert syndrome. Based on their ability to catalyze the glucuronidation of xenobiotics and endobiotics, UGTs play a critical role in hormonal homeostasis, energy metabolism, bilirubin clearance and xenobiotic detoxification. UDP-glucuronosyltransferase 1A1 (UGT1A), also designated Bilirubin specific UDPGT isozyme 1 (HUG-BR1), is crucial in the conjugation and elimination of toxic zenobiotics and endogenous compounds. Defects in UGT1A1 may cause transient familial neonatal hyperbilirubinemia associated with breast milk, which is characterizied by excessive concentration of bilirubin in the blood, leading to jaundice.
Host	Rabbit
Immunogen	Recombinant full length Human UGT1A1.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P22309
Uniprot	P22309
Weight	59 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: UGT1A1 polyclonal antibody detects endogenous levels of UGT1A1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11307947	BS7952	50µl	$234.89		Add to Cart
BHA11307947	BS7952	100µl	$368.22		Add to Cart

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