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Home / Primary Antibodies / Recombinant Antibodies

Anti-EVPL Antibody BHA11306408

SKU : BHA11306408

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Mfr.No.	BS71605
Alternative Names	EVPK
Antigen	EVPL
Categories	Primary Antibodies
Chromosome Location	17q25.1
Clonality	polyclonal
Description	Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that is associated with underlying neoplasms. PNP sera react with multiple plakin family proteins, among which only envoplakin and periplakin are constantly detected. Envoplakin, a membrane-associated precursor of the epidermal cornified envelope and desmosomes, is a member of the plakin family of proteins. Envoplakin is expressed in epidermal and esophageal keratinocytes and nonepithelial stratified squamous epithelia, but not in simple epithelia or nonepithelial cells. Envoplakin co-localizes with desmoplakin at desmosomes and on keratin filaments throughout the differentiated layers of the epidermis, but mainly accumulates in nuclear and cytoplasmic aggregates with associated intermediate filaments. The envoplakin rod domain is required for aggregation and the linker domain is required for intermediate filament association. The distribution of envoplakin at the interdesmosomal plasma membrane depends on heterodimerization with periplakin
Host	Rabbit
Immunogen	Recombinant protein of human EVPL
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92817
Uniprot	Q92817
Weight	Predicted band size: 232 kDaObserved band size: Refer to Figures

Description	Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Specificity: EVPL polyclonal antibody detects endogenous levels of EVPL protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11306408	BS71605	50µl	$234.89		Add to Cart
BHA11306408	BS71605	100µl	$368.22		Add to Cart

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