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Home / Primary Antibodies / Recombinant Antibodies

Anti-UCHL5 Antibody BHA11305810

SKU : BHA11305810

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Mfr.No.	BS71027
Alternative Names	UCH37 ; CGI-70 ; INO80R ; UCH-L5
Categories	Primary Antibodies
Chromosome Location	1q31.2
Clonality	polyclonal
Description	UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGF∫-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
Host	Rabbit
Immunogen	Recombinant protein of human UCHL5.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9Y5K5
Uniprot	Q9Y5K5
Weight	38 kDa

Description	Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Specificity: UCHL5 polyclonal antibody detects endogenous levels of UCHL5 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305810	BS71027	50µl	$234.89		Add to Cart
BHA11305810	BS71027	100µl	$368.22		Add to Cart

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