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Home / Primary Antibodies / Recombinant Antibodies

Anti-FBXW7 Antibody BHA11305493

SKU : BHA11305493

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Mfr.No.	BS70690
Alternative Names	AGO ; CDC4 ; FBW6 ; FBW7 ; hAgo ; FBX30 ; FBXW6 ; SEL10 ; hCdc4 ; FBXO30 ; SEL-10
Antigen	FBXW7
Categories	Primary Antibodies
Chromosome Location	4q31.3
Clonality	polyclonal
Description	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Host	Rabbit
Immunogen	Recombinant protein of human FBXW7.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q969H0
Uniprot	Q969H0
Weight	79 kDa

Description	Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Specificity: FBXW7 polyclonal antibody detects endogenous levels of FBXW7 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305493	BS70690	50µl	$234.89		Add to Cart
BHA11305493	BS70690	100µl	$368.22		Add to Cart

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