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Home / Primary Antibodies / Recombinant Antibodies

Anti-CDKN2D Antibody BHA11305149

SKU : BHA11305149

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Mfr.No.	BS6940
Alternative Names	Cyclin-dependent kinase 4 inhibitor D ; p19-INK4d ; CDKN2D
Categories	Primary Antibodies
Chromosome Location	19p13.2
Clonality	polyclonal
Description	The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6, which are subject to inhibition by the mitotic inhibitory protein, p16. Isolated members of the p16 family have been designated p15, p18 and p19. p15 expression is upregulated approximately 30-fold in TGF ß-treated human keratinocytes, suggesting that p15 may function as an effector of TGF ß-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases. The gene encoding p15 has been mapped to chromosome 9p21.3 at a position adjacent to the p16 gene, at a site of frequent chromosomal abnormality in human tumors. Two p16- related proteins, p19 and p18, specifically inhibit the kinase activities of Cdk4 and Cdk6 but do not affect those of cyclin E-Cdk2, cyclin A-Cdk2 or cyclin B-Cdc2 complexes. p19 is expressed at maximal level during S phase, while overexpression of p19 leads to G1 arrest.
Host	Rabbit
Immunogen	Recombinant full length Human CDKN2D.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P55273
Uniprot	P55273
Weight	18 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: CDKN2D polyclonal antibody detects endogenous levels of CDKN2D protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305149	BS6940	50µl	$234.89		Add to Cart
BHA11305149	BS6940	100µl	$368.22		Add to Cart

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