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Home / Primary Antibodies / Recombinant Antibodies

Anti-FLNB Antibody BHA11305222

SKU : BHA11305222

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Mfr.No.	BS70102
Alternative Names	Filamin-B ; Filamin B ; FilaminB ; FLN-B ; ABP-278 ; ABP-280 homolog ; Actin-binding-like protein ; Beta-filamin ; Filamin homolog 1 ; Fh1 ; Filamin-3 ; Thyroid autoantigen ; Truncated actin-binding protein ; Truncated ABP ; FLNB ; FLN1L ; FLN3 ; TABP ; TAP
Antigen	FLNB
Categories	Primary Antibodies
Chromosome Location	3p14.3
Clonality	polyclonal
Description	Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alpha-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta integrins, Rho/Rac/Cdc42, PKC, and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1-mediated actin cytoskeleton reorganization (4).
Host	Rabbit
Immunogen	Recombinant protein of human FLNB.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O75369
Uniprot	O75369
Weight	278 kDa

Description	Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Specificity: FLNB polyclonal antibody detects endogenous levels of FLNB protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305222	BS70102	50µl	$234.89		Add to Cart
BHA11305222	BS70102	100µl	$368.22		Add to Cart

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