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Home / Primary Antibodies / Recombinant Antibodies

Anti-UPF1 Antibody BHA11305074

SKU : BHA11305074

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Mfr.No.	BS6836
Alternative Names	Regulator of nonsense transcripts 1 ; ATP-dependent helicase RENT1 ; Nonsense mRNA reducing factor 1 ; NORF1 ; Up-frameshift suppressor 1 homolog ; hUpf1 ; UPF1 ; KIAA0221 ; RENT1
Categories	Primary Antibodies
Chromosome Location	19p13.11
Clonality	polyclonal
Description	Upf1 was identified as an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. Upf1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodies. Upf1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machinery. Two other active components of NMD, Upf2 and Upf3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.
Host	Rabbit
Immunogen	Recombinant full length Human UPF1.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92900
Uniprot	Q92900
Weight	130 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: UPF1 polyclonal antibody detects endogenous levels of UPF1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305074	BS6836	50µl	$234.89		Add to Cart
BHA11305074	BS6836	100µl	$368.22		Add to Cart

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