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Home / Primary Antibodies / Recombinant Antibodies

Anti-CDKN1C Antibody BHA11305102

SKU : BHA11305102

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Mfr.No.	BS6876
Alternative Names	Cyclin-dependent kinase inhibitor 1C ; Cyclin-dependent kinase inhibitor p57 ; p57Kip2 ; CDKN1C ; KIP2
Categories	Primary Antibodies
Chromosome Location	11p15.4
Clonality	polyclonal
Description	p57 / Kip 2 (or CDKN 1C) is a potent tight binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57 / Kip 2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith Wiedemann syndrome (BWS, a cancer syndrome) making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin like growth factor II (IGF II) and H19, both of which seem to be implicated in adrenal neoplasms.
Host	Rabbit
Immunogen	Recombinant full length Human CDKN1C.
Reactivity	Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P49918
Uniprot	P49918
Weight	57 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: CDKN1C polyclonal antibody detects endogenous levels of CDKN1C protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305102	BS6876	50µl	$234.89		Add to Cart
BHA11305102	BS6876	100µl	$368.22		Add to Cart

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