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Home / Primary Antibodies / IHC Antibodies

Anti-BRCA1 Antibody BHA11304775

SKU : BHA11304775

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Mfr.No.	BS6423
Alternative Names	Breast cancer type 1 susceptibility protein ; RING finger protein 53 ; BRCA1 ; RNF53
Categories	Primary Antibodies
Chromosome Location	17q21.31
Clonality	polyclonal
Description	BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Host	Rabbit
Immunogen	Recombinant full length Human BRCA1.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P38398
Uniprot	P38398
Weight	200 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: BRCA1 polyclonal antibody detects endogenous levels of BRCA1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:2000
IHC/IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304775	BS6423	50µl	$234.89		Add to Cart
BHA11304775	BS6423	100µl	$368.22		Add to Cart

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