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Home / Primary Antibodies / IHC Antibodies

Anti-NEDD8 Antibody BHA11304596

SKU : BHA11304596

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Mfr.No.	BS6197
Alternative Names	NEDD8 ; Neddylin ; Neural precursor cell expressed developmentally down-regulated protein 8 ; NEDD-8 ; Ubiquitin-like protein Nedd8 ; NEDD8
Antigen	NEDD8
Categories	Primary Antibodies
Chromosome Location	14q12
Clonality	polyclonal
Description	NEDD8 is a ubiquitin (Ub)-like molecule that shares 80% homology with ubiquitin, a protein known to modify and target various proteins for proteolytic degradation. NEDD8 and the corresponding yeast homolog RUB1 are activated by the E1 ubiquitin activating enzyme UBA2, which forms isopeptide linkages between thio esters. Similar to the Ub-mediated proteolytic pathway, NEDD8 is covalently coupled to an E3 Ub ligase by the E2 conjugating enzyme, UBC12. NEDD8 preferentially associates with the CUL-2 protein in the E3 ligase complex CBCVHL, which consists of cullin proteins associating with elongin B/C and the tumor suppressor F-box protein von Hippel Lindau (VHL). NEDD8 is predominantly localized to the nucleus and is highly expressed in adult heart and skeletal muscle. In vitro studies indicate that NEDD8 tetramers are also able to bind to the 26S proteasome, and that they assemble into complexes with conserved Ub-like moieties, suggesting that NEDD8 may regulate proteolysis of intracellular proteins similar to other Ub-mediated pathways.
Host	Rabbit
Immunogen	Recombinant full length Human Neddylin / NEDD8.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q15843
Uniprot	Q15843
Weight	9 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: NEDD8 polyclonal antibody detects endogenous levels of NEDD8 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304596	BS6197	50µl	$234.89		Add to Cart
BHA11304596	BS6197	100µl	$368.22		Add to Cart

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