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Home / Primary Antibodies / Recombinant Antibodies

Anti-ARHGEF7 Antibody BHA11304292

SKU : BHA11304292

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Mfr.No.	BS6154
Alternative Names	PIXβ ; Rho guanine nucleotide exchange factor 7 ; Beta-Pix ; COOL-1 ; PAK-interacting exchange factor beta ; p85 ; ARHGEF7 ; COOL1 ; KIAA0142 ; P85SPR ; PAK3BP ; PIXB ; Nbla10314
Categories	Primary Antibodies
Chromosome Location	13q34
Clonality	polyclonal
Description	The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, α and β, and both are highly expressed in heart, muscle and thymus tissues of human and rat. αPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The αPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
Host	Rabbit
Immunogen	Recombinant full length Human ARHGEF7.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q14155
Uniprot	Q14155
Weight	90 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: ARHGEF7 polyclonal antibody detects endogenous levels of ARHGEF7 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304292	BS6154	50µl	$234.89		Add to Cart
BHA11304292	BS6154	100µl	$368.22		Add to Cart

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