Integrated AAV Offerings: From Cutting-Edge Products to Advanced Custom Services

Premade AAV Serotypes and Target Tissues/Cells

The following table provides a view of premade AAV serotypes that are suitable for targeting specific tissues and cell types, helping researchers choose the most appropriate vectors for their studies.

Newly added AAV Serotypes and Target Tissues/Cells

The following table provides a view of on new serotypes that have specific targeting capabilities, particularly for the central nervous system and brain-related applications.

All the AAV serotypes listed above, including the newly available options such as AAV/11, AAV/B10, AAV/B22, AAV/Mac, AAV/BR1, and AAV/BI30, can be selected when ordering our premade rAAVs. These serotypes are designed to target specific tissues and cells, providing you with versatile options for your gene delivery and research needs. Whether you're focusing on CNS applications, retrograde targeting, or vascular endothelial cells, we have a suitable AAV serotype ready to support your project.

AAV Products categorized by function

Our pre-made AAVs are categorized by functions such as Biosensors, Chemogenetics, Controls, Optogenetics, and Recombinases, aiding researchers in selecting the appropriate AAV products for different research applications.

Chemogenetics AAV​

Chemogenetics is an innovative technique that combines genetic engineering with the use of specific chemical compounds to control cell activity, particularly in neuroscience and cell signaling studies. Chemogenetics AAV (Adeno-Associated Virus) vectors are designed to deliver genes encoding engineered receptors, such as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), into targeted cells or tissues. These engineered receptors are inert under normal physiological conditions but can be selectively activated or inhibited by synthetic ligands, allowing precise control over neuronal activity, signaling pathways, and cellular functions.
 

​Biosensor AAV

Biosensor AAV (Adeno-Associated Virus) vectors are powerful tools used to study dynamic biological processes in real time by delivering genes encoding biosensors into specific cells or tissues. These biosensors are genetically encoded fluorescent or luminescent proteins that can report changes in cellular environments, such as calcium levels, pH, voltage, neurotransmitter release, and other molecular interactions. When delivered using AAV vectors, these biosensors provide long-term and targeted expression in living cells or organisms, allowing researchers to monitor physiological changes with high precision.

​
Neurotransmitter sensor

Neurotransmitter sensor AAV (Adeno-Associated Virus) vectors are specialized tools designed to monitor neurotransmitter dynamics in real time within the nervous system. These AAV vectors deliver genes encoding genetically encoded neurotransmitter sensors (such as G-protein-coupled receptor-based sensors) to specific neurons or brain regions. These sensors can detect the release and uptake of neurotransmitters like glutamate, dopamine, serotonin, acetylcholine, and others, providing a powerful means to study synaptic transmission, neural circuit activity, and neurochemical signaling.
​

Optogenetics AAV

Optogenetics AAV (Adeno-Associated Virus) vectors are revolutionary tools in neuroscience and cellular biology that enable precise control of cellular activity using light. Optogenetics involves genetically encoding light-sensitive proteins, such as channelrhodopsins, halorhodopsins, or opsins, into specific neurons or cells. When these proteins are expressed via AAV vectors, they allow researchers to activate or inhibit targeted cells with millisecond precision by simply shining light of specific wavelengths. This technique provides unprecedented control over neural circuits, cellular signaling pathways, and physiological processes.
 

​
​Recombinase

Recombinase AAV (Adeno-Associated Virus) vectors are advanced tools used in genetic engineering to achieve targeted and precise DNA recombination in specific cells or tissues. These vectors deliver genes encoding recombinase enzymes, such as Cre, Flp, or Dre recombinases, which recognize specific DNA sequences (loxP, FRT, or rox sites, respectively) to catalyze the deletion, inversion, or translocation of genetic material. Recombinase systems are widely used to control gene expression, study gene function, and create conditional knockout or knock-in models.
​