Radicicol

Mfr.No.	SIH-117
Appearance	White to Yellow Solid
Function	Hsp90 inhibitor
Inchi	InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
Inchikey	WYZWZEOGROVVHK-GTMNPGAYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C18H17CIO6
Pubchem Cid	6323491
Published Application	Competitive binding assay
Published Species Reactivity	Human
Pubmed Id	20220516
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	COc1ccc2c(=O)c(coc2c1OC)c3cc(c(cc3I)OC)OC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	12772-57-5
Molecular Weight	364.8
Scientific Background	Radicicol inhibits src (IC50=0.27µM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Solubility	Soluble in DMSO
Source	Produced by fermentation
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	97% by TLC
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929. 2. Yen A., et al. (1994) Exp.Cell Res. 214: 163. 3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221. 4. Soga S., et al. (1998) J.Biol.Chem. 273: 822. 5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221. 6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900008-1	SIH-117A	1 mg	$138		Add to Cart

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Radicicol

Rate it now..!!