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Home / Proteins & Peptide

Yes1, GST-tag

SKU : BHP18200258

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Mfr.No.	40488
Description	Human, full length, YES1, also known as Yes, c-yes, HsT441, P61-YES GenBank Accession No. NM_005433, with N-terminal GST tag, a.a. 2- 543(end), MW 88 kDa, expressed in Sf9 insect cells via a baculovirus expression system. Host cell line: Sf9 cells Specific activity: 200 pmole/min/ug
Background	YES1 is the cellular homolog of the Yamaguchi sarcoma virus oncogene that has tyrosine kinase activity and belongs to the SRC family. YES1 lies in close proximity to thymidylate synthase gene on chromosome 18 and chromosome 22 (1). The activation of YES1 may play a significant role in the malignant transformation of hepatocytes, and is important for maintaining embryonic stem cells in an undifferentiated state. YES1 is a useful marker to detect early-stage hepatocellular carcinoma, and it plays a key role in the tumorigenesis and metastasis of gastric cancer. YES1 induction results in increased cancer cell motility suggesting that YES1 may promote cancer spread and metastasis rather than tumor growth (2).
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 3mM DTT, and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assay was done inKinase buffer containing 0.2 mM DTTusing Poly-(Glu4:Tyr)-biotin substrate(0.2 mg/ml) and 20 uM ATP. Reactionwas done at 30°C for 45 min. Amount ofATP transferred was calculated usingKinase-Glo reagent (Promega) Avoid freeze/thaw cycles.
GenBank	NM_005433
Mw(kda)	91 kDa

Synonyms	Yes, c-yes, HsT441, P61-YES
Uniprot	P07947

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Silverman, G. et.al, Genomics 15: 442-445, 1993. 2. Barraclough, J. et al, Neoplasia. 2007 Sep;9(9):745-54.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200258	40488	10 ug	$423.50		Add to Cart

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