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Home / Proteins & Peptide

WDR5, His-tag

SKU : BHP18200633

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Mfr.No.	71200
Description	Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
Background	As part of the MLL1/MLL complex, WDR5 is involved in methylation and dimethylation at Lys4 of histone H3, which is a specific tag for epigenetic transcriptional activation. As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. WDR5 may regulate osteoblasts differentiation. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes WDR5 contains 7 WD repeats.
Immunogen Region	2-334(end)
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_017588
Mw(kda)	37.5 kDa

Synonyms	WDR5, WD Repeat Domain 5, SWD3, BIG-3, Set1c WD40 Repeat Protein, BMP2-Induced 3-Kb Gene Protein
Uniprot	P61964

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Trievel, R.C., Shilatifard, A. (2009). Nature Struct. Mol. Biol. 16 (7): 678-80. 2. Wang, Y.Y., et al. (2010). Proc. Natl. Acad. Sci. USA 107(2):815-20. 3. Odho, Z., et al. (2010). J. Biol. Chem. 285(43):32967-76

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200633	71200	100 ug	$506		Add to Cart

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