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Home / Proteins & Peptide

VEGF R2/KDR, Human

SKU : BHP18500484

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iXCells Biotechnologies

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Mfr.No.	IX03366, IX03366-50
Description	Vascular endothelial growth factor receptor 2 (VEGF R2) , also known as Kinase insert domain receptor (KDR) and Fetal Liver Kinase 1 (Flk-1), is a type III receptor tyrosine kinase which plays a critical role in angiogenesis. VEGFR-1 and VEGFR-2 are closely related receptor tyrosine kinases and have both common and specific ligands. VEGFR-1 is a kinase-impaired RTK whereas VEGFR-2 is a highly active kinase. Vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) as well as blood-vessel formation (angiogenesis) in the adult. In mammals, five VEGF ligands, which occur in several different splice variants and processed forms, have been identified so far. These ligands bind in an overlapping pattern to three receptor tyrosine kinases (RTKs), known as VEGF receptor-1, -2 and -3 (VEGFR1-3), as well as to co-receptors (here defined as VEGF-binding molecules that lack established VEGF-induced catalytic function), such as heparin sulphate proteoglycans (HSPGs) and neuropilins. Recombinant Human VEGF R2/KDR produced in CHO cells is a polypeptide chain containing 978 amino acids. rhVEGFR2/KDR has a molecular mass of 150 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	150 kDa, observed by reducing SDS-PAGE.
Source	CHO
Accession Number	P35968
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	Measured by its ability to inhibit the VEGF dependent proliferation of HUVEC (human umbilical vein endothelial cells).The ED50 for this effect is 30 ng/mL in the presence of 5 ng/mL rhVEGF165 (Catalog: Z02689-10).

Synonyms	CD309; Flk-1; KDR
Sequence	ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDLDWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTGAYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT?ENKNKTVVIPCLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPSYMISYAGMVF?CEAKINDESY QSIMYIVVVV GYRIYDVVLS PSHGIELSVGEKLVLNCTAR TELNVGIDFN?WEYPSSKHQH KKLVNRDLKT QSGSEMKKFLSTLTIDGVTR SDQGLYTCAA SSGLMTKKNS?TFVRVHEKPF VAFGSGMESLVEATVGERVR IPAKYLGYPP PEIKWYKNGI PLESNHTIKA?GHVLTIMEVSERDTGNYTVI LTNPISKEKQ SHVVSLVVYV PPQIGEKSLISPVDSYQYGT?TQTLTCTVYA IPPPHHIHWY WQLEEECANE PSQAVSVTNPYPCEEWRSVE DFQGGNKIEV?NKNQFALIEG KNKTVSTLVI QAANVSALYKCEAVNKVGRG ERVISFHVTR GPEITLQPDM?QPTEQESVSL WCTADRSTFENLTWYKLGPQ PLPIHVGELP TPVCKNLDTL WKLNATMFSN?STNDILIMELKNASLQDQGD YVCLAQDRKT KKRHCVVRQL TVLERVAPTITGNLENQTTS?IGESIEVSCT ASGNPPPQIM WFKDNETLVE DSGIVLKDGNRNLTIRRVRK EDEGLYTCQA?CSVLGCAKVE AFFIIEGAQE KTNLEIEGRMDDKTHTCPPC PAPELLGGPS VFLFPPKPKD?TLMISRTPEV TCVVVDVSHEDPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL?HQDWLNGKEYKCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMTKNQVSLTCLV?KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSKLTVDKSRWQQ GNVFSCSVMH?EALHNHYTQK SLSLSPGK

Purity	98% as analyzed by SDS-PAGE HPLC.
Storage	Lyophilized recombinant Human VEGF R2/KDR remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human VEGF R2/KDR should be stable up to 1 week at 4°C or up to 3 months at -20°C.For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500484-1	IX03366-50	50ug	$187		Add to Cart

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