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Home / Proteins & Peptide

VEGF R1/Flt1, Human

SKU : BHP18500483

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iXCells Biotechnologies

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Mfr.No.	IX03365, IX03365-50
Description	Vascular endothelial growth factor receptor 1 (VEGF R1) , also known as FMS-like tyrosine kinase (Flt1), is a receptor tyrosine kinase which plays a critical role in angiogenesis. Human VEGF R1 contains a signal peptide (aa 1-22), an extracellular domain (ECD aa 27-758) with seven Ig-like repeats, a trans-membrane domain (aa 759-780) and a cytoplasmic region (aa 781-1338) with a tyrosine kinase domain and several autocatalytic phosphotyrosine sites. VEGFR-1 and VEGFR-2 are closely related receptor tyrosine kinases and have both common and specific ligands. VEGFR-1 is a kinase-impaired RTK whereas VEGFR-2 is a highly active kinase. Vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) as well as blood-vessel formation (angiogenesis) in the adult. In mammals, five VEGF ligands, which occur in several different splice variants and processed forms, have been identified so far. These ligands bind in an overlapping pattern to VEGF receptor-1, -2 and -3 (VEGFR1-3), as well as to co-receptors (here defined as VEGF-binding molecules that lack established VEGF-induced catalytic function), such as heparin sulphate proteoglycans (HSPGs) and neuropilins. Recombinant Human VEGF R1 produced in CHO cells is a polypeptide chain containing 535 amino acids. rhVEGF R1 has a molecular mass of 80 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	80 kDa, observed by reducing SDS-PAGE.
Source	CHO
Accession Number	P17948
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	Measured by its ability to inhibit the VEGF dependent proliferation of HUVEC (human umbilical vein endothelial cells).The ED50 for this effect is 30 ng/mL in the presence of 2.5 ng/mL rhVEGF165 (Catalog: Z02689-10).

Synonyms	FLT1; Flt-1
Sequence	SKLKDPELSL KGTQHIMQAG QTLHLQCRGE AAHKWSLPEMVSKESERLSI TKSACGRNGK?QFCSTLTLNT AQANHTGFYS CKYLAVPTSKKKETESAIYI FISDTGRPFV EMYSEIPEII?HMTEGRELVI PCRVTSPNITVTLKKFPLDT LIPDGKRIIW DSRKGFIISN ATYKEIGLLT?CEATVNGHLYKTNYLTHRQT NTIIDVQIST PRPVKLLRGH TLVLNCTATTPLNTRVQMTW?SYPDEKNKRA SVRRRIDQSN SHANIFYSVL TIDKMQNKDKGLYTCRVRSG PSFKSVNTSV?HIIEGRMDDK THTCPPCPAP ELLGGPSVFLFPPKPKDTLM ISRTPEVTCV VVDVSHEDPE?VKFNWYVDGV EVHNAKTKPREEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI?EKTISKAKGQPREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWESNGQPENNYK?TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEALHNHYTQKSLS LSPGK

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Human VEGF R1/Flt-1 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human VEGF R1/Flt-1 should be stable up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500483-1	IX03365-50	50ug	$199		Add to Cart

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