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Home / Proteins & Peptide

ULK1, FLAG-tag

SKU : BHP18200171

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BPS Bioscience

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Mfr.No.	40099
Description	Human ULK1 (UNC-51-Like Kinase-1), also known as ATG1 (Autophagy related protein 1), GenBank Accession No. NM_003565, a.a. 2-end with N-terminal FLAG-tag, MW = 113 kDa, expressed in FreeStyle 293-F cells. host species: human Host species: human Host cell line: FreeStyle 293-F cells
Background	ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Immunogen Region	2-end
Tag	N-terminal FLAG-tag
Formulation	25 mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05% Tween-20, 100 ug/ml FLAG peptide, 20% glycerol and 3 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_003565
Mw(kda)	113 kDa

Synonyms	ATG1, UNC51, Unc51.1, FLJ38455, Unc-51-Like Kinase, Autophagy-Related Protein 1
Uniprot	O75385

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Ganley I.G. et al., J. Biol. Chem. 284 (18), 12297-12305 (2009). 2. Chan E.Y. et al., Mol. Cell. Biol. 29 (1), 157-171 (2009).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200171	40099	10 ug	$445.50		Add to Cart

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