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Home / Proteins & Peptide

TRAIL/Apo2L, Human

SKU : BHP18500289

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iXCells Biotechnologies

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Mfr.No.	IX03124, IX03124-1, IX03124-10, IX03124-50
Description	TRAIL/Apo2L, also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10), is a pleiotropic cytokine thatbelongs to the TNF superfamily. The full length TRAIL expressed in vivo is a Type II transmembrane protein, although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5, two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, recruits the FAS-associated death domain, activates caspases 8 and 10, and eventually leads to apoptosis. Because of its antitumor potential, TRAIL is actively studied as a therapeutic agent. On the other hand, abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells, resulting in increasing vascular remodeling and pulmonary arterial hypertension. Recombinant human TRAIL/Apo2L (rhTRAIL) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhTRAIL has a molecular mass of 19.6 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	19.6 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P50591
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 40 ng/mL, measured by the cell growth inhibitory assay using RPMI-8226 cells, corresponding to a specific activity of 2.5 x 104 units/mg.

Synonyms	TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2
Sequence	MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKINSWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRFQEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWSKDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEASFFGAFLVG

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant human TRAIL/Apo2L (rhTRAIL) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhTRAIL remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500289-1	IX03124-1	1mg	$698		Add to Cart
BHP18500289-2	IX03124-10	10ug	$49		Add to Cart
BHP18500289-3	IX03124-50	50ug	$107		Add to Cart

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