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Home / Proteins & Peptide

TPO, His, Mouse

SKU : BHP18500492

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iXCells Biotechnologies

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Mfr.No.	IX03374, IX03374-1, IX03374-10, IX03374-50
Description	Thrombopoietin(TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.?Recombinant mouse TPO produced in HEK293 cells with C-terminal Histidine tag, is a polypeptide chain containing 341 amino acids. rmTPO has a molecular mass of 62~70 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted insterile ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized from a 0.2 um filtered solution in PBS.
Molecular Weight	62-70kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Mouse
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 2ng/ml, measured in a proliferation assay using MO7e cells.

Synonyms	C-mpl ligand, MGDF, Thpo; MGDF
Sequence	SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVLLPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQLEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTAHKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTAVPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSRLQGFRVKITP GQLNQTSRSP VQISGYLNRT HGPVNGTHGLFAGTSLQTLE ASDISPGAFN KGSLAFNLQG GLPPSPSLAPDGHTPFPPSP ALPTTHGSPP ?QLHPLFPDPS TTMPNSTAPH PVTMYPHPRNLSQETHHHHH H

Purity	97% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant Mouse TPO remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Mouse TPO should be stable up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500492-1	IX03374-1	1mg	$2097		Add to Cart
BHP18500492-2	IX03374-10	10ug	$107		Add to Cart
BHP18500492-3	IX03374-50	50ug	$245		Add to Cart

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