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Home / Proteins & Peptide

TNF-alpha, Human

SKU : BHP18500007

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iXCells Biotechnologies

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Mfr.No.	IX01001, IX01001-1, IX01001-10, IX01001-50
Description	Tumor Necrosis Factor-alpha (TNF-a) is a homotrimer with a subunit molecular mass of 17.3 kDa. Tumor Necrosis Factor-alpha(TNF-a) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease.Recombinant Human Tumor Necrosis Factor-alpha (TNF-alpha) produced in E.coli is a single non-glycosylated polypeptide chain containing 157 amino acids. A fully biologically active molecule, rhTNF-alpha has a molecular mass of 17.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	17.3 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Endotoxin Level	Less than 0.2 EU/ug determined by LAL test.
Notes	For research use only
Bioactivity	ED50 30 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of 3.3 x 107 units/mg.

Synonyms	TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2
Sequence	VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANGVELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTISRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYLGGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL

Purity	98% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Human Tumor Necrosis Factor-alpha (TNF-alpha), remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human TNF-alpha should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500007-1	IX01001-1	1mg	$781		Add to Cart
BHP18500007-2	IX01001-10	10ug	$62		Add to Cart
BHP18500007-3	IX01001-50	50ug	$120		Add to Cart

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