Human TIM-3, also known as T-cellimmunoglobulin mucin receptor 3, T-cellmembrane protein 3, TIMD-3, Hepatitis Avirus cellular receptor 2, HAVCR-2, andKIM-3 with a C-terminal FLAG-tag. GenBankAccession No. NM_032782.4, a.a. 22-200expressed in a HEK293 cell expressionsystem. MW = 20.8 kDa. This protein runsat a higher MW by SDS-PAGE due toglycosylation.
Immunogen Region
22-200
Tag
C-terminal, FLAG-tag
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species
Human
Application
Useful for studying protein binding and for screening small molecules and antibodies.
Endotoxin Level
<1 EU/ug
Notes
The aggregation state of this product has been confirmed to be<10%. Avoid freeze/thaw cycles. Protein may be diluted to>=100 ug/ml in PBS + glycerol and stored at -80°C.
GenBank
NM_032782.4
Mw(kda)
20.8 kDa
Synonyms
T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIMD-3, Hepatitis A virus cellular receptor 2, HAVCR-2 KIM-3, Tim
Uniprot
Q8TDQ0
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. Zhu, C. et al., Nat. Immunol. 2005; 6:1245-1252. 2. Anderson, A.C. et al., Science. 2007; 318(5853):1141-1143.