Human TIM-3, also known as T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIMD-3, Hepatitis A virus cellular receptor 2, HAVCR-2, and KIM-3. GenBank Accession No. NM_032782, a.a. 22-200 with a C-terminal Avi-His-tag, expressed in a HEK293 cell expression system. MW = 23 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Immunogen Region
22-220
Tag
C-terminal Avi-His-Tag
Formulation
8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol.
Species
Human
Application
Useful for studying protein binding and for screening small molecules and antibodies.
Notes
Avoid freeze/thaw cycles.
GenBank
NM_032782
Mw(kda)
23 kDa
Uniprot
Q8TDQ0
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C. Avoid freeze/thaw cycles. Protein may be diluted to>= 100ug/ml in PBS + glycerol and stored at -80°C.
Reference
1. Zhu, C. et al., Nat. Immunol. 2005; 6:1245-1252.2. Anderson, A.C. et al., Science. 2007; 318(5853):1141-1143.