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Home / Proteins & Peptide

TGF-beta1, Human

SKU : BHP18500509

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Mfr.No.	IX03411, IX03411-1, IX03411-10, IX03411-50
Description	TGF-beta1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta1 superfamily that share a characteristic cystine knot structure. TGF-beta1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant function; for TGF-beta1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-beta1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-beta RI (also called activin receptor?like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription.?Recombinant Human TGF-beta1 produced in CHO cells is a polypeptide chain containing 112 amino acids. A fully biologically active molecule, rhTGF-beta1 has a molecular mass of 12 kDa, analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH?O or 50mM Citrate at 100 ug/ml.
Formulation	Lyophilized from a 0.2 um filtered solution in 50mM NaAc, 50mM NaCl, pH 5.0.
Molecular Weight	12 kDa, observed by reducing SDS-PAGE.
Source	CHO
Host	Human
Accession Number	P01137
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED?? 0.2ng/mL, measured in ability to inhibit the mouse IL-4-dependent proliferation of HT-2 cells.

Synonyms	TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1; TGF-?1; TGF?1
Sequence	ALDTNYCF SSTEKNCC VRQLYIDF RKDLGWKW IHEPKGYH?ANFCLGPC PYIWSLDT QYSKVLAL YNQHNPGA SAAPCCVP?QALEPLPI VYYVGRKP KVEQLSNM IVRSCKCS

Purity	95% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant TGF-beta1 remains stable for up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TGF-beta1 should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it;s recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500509-1	IX03411-1	1mg	$3744		Add to Cart
BHP18500509-2	IX03411-10	10ug	$188		Add to Cart
BHP18500509-3	IX03411-50	50ug	$469		Add to Cart

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