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Home / Proteins & Peptide

TC-PTP(PTPN2), GST-tag

SKU : BHP18200030

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BPS Bioscience

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Mfr.No.	30013
Description	Human recombinant TC-PTP, also known as PTPN2 (protein tyrosine phosphatase N2), Genbank accession No. BC016727, a.a. 2-315 (catalytic domain), with N-terminal GST tag, MW=62.3 kDa, expressed in an E. coli expression system. Specific activity: 463 pmole/min/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.
Immunogen Region	2-315
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. Avoid freeze/thaw cycles.
GenBank	BC016727
Mw(kda)	62.3 kDa

Synonyms	PTPN2, TC-PTP, PTPT, TCELLPTP, TCPTP
Uniprot	P17706

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. N.F. Zander et al., Biochemistry 1991, 30: 6964. 2. D.E. Cool et al., Proc. Natl. Acad. Sci. USA 86: 5257.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200030	30013	50 ug was 20 ug	$357.50		Add to Cart

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