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Home / Proteins & Peptide

TBK1, GST-tag

SKU : BHP18200218

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BPS Bioscience

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Mfr.No.	40286
Description	Recombinant human TBK1, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. Host cell line: Sf9 cells
Background	TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases (1). Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon (2).
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	BC034950
Mw(kda)	105 kDa

Synonyms	NAK, T2K, FLJ11330
Uniprot	Q9UHD2

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=75%
Storage	At least 6 months at -80°C.

Reference	1. Tojima, Y. et al: NAK is an I-kappa-B kinase-activating kinase. Nature 404: 778-782, 2000. 2. Sharma, S. et al: Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151, 2003.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200218	40286	10 ug	$412.50		Add to Cart

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