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Home / Proteins & Peptide

STK4(MST1), GST-tag

SKU : BHP18200138

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Mfr.No.	40017
Description	Human STK4 (serine/threonine kinase 4), also known as MST-1 (Mammalian STE20-like protein kinase 1) or KRS2, GenBank Accession No. NM_006282, a.a. 2-488(end), with N-terminal GST-tag, MW=81.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: 73 pmole/min/ug
Background	MST1 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20). Endogenous full-length MST1 is activated by a variety of stressful stimuli, accompanied by the secondary appearance of a 36 kDa Thr183-phosphorylated, caspase-cleaved catalytic fragment. Recombinant MST1 undergo a robust autoactivation in vitro, mediated by an intramolecular autophosphorylation on the activation loop of an MST dimmer. MST1 can initiate apoptosis when transiently overexpressed in mammalian cells. Interference with the ability of endogenous MST1 to associate with the putative tumor suppressor proteins Nore1/RASSF can inhibit Ras-induced apoptosis.
Immunogen Region	2-488(end)
Tag	N-terminal GST-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 18 mM glutathione, and 10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH 7.5), 10 mM MgCl₂, 1 mM EGTA, 200 uM ATP, 0.01% Brij-35 and 2 uM substrate (Ser/Thr Peptide 7, Invitrogen) at 30°C for 1 hour. Avoid freeze/thaw cycles.
GenBank	NM_006282
Mw(kda)	81.5 kDa

Synonyms	KRS2; YSK3; DKFZp686A2068; STK4
Uniprot	Q13043

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Taylor, L.K., et al. (1996). Proc. Natl. Acad. Sci. USA. 93(19):10099-104. 2. Song, H., et al. (2010). Proc. Natl. Acad. Sci. USA. 107(4):1431-6. 3. Ura, S., et al. (2001). Proc. Natl. Acad. Sci. USA. 98(18):10148-53.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200138	40017	10 ug	$390.50		Add to Cart

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