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Home / Proteins & Peptide

STK33, GST-tag

SKU : BHP18200167

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BPS Bioscience

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Mfr.No.	40093
Description	STK33 (GenBank Accession No. NM_030906.2), a.a. 2-end, with N-terminal GST-tag, MW = 84 kDa, expressed in a Baculovirus-infected Sf9 cell expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: 2.8 pmol/min/ug
Background	STK33 is a distant member of the CAMK group of serine/threonine kinases but it lacks the calcium/calmodulin-binding domain and the C-terminal regulatory tail. STK33 is highly expressed in testis, lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. STK33 is essential for abnormal cell growth in human cell lines expressing oncogenic mutations in KRAS, but not in human cancer cell lines expressing wildtype KRAS. STK33 is required for survival and proliferation of mutant KRAS-dependent cancer cells, in which it suppresses the S6K1-BAD proapoptotic signaling pathway.
Immunogen Region	2-end
Tag	N-terminal GST-tag
Formulation	45 mM Tris-HCl, pH 8.0, 115 mM NaCl, 10% glycerol, and 2 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assayed using 5 ug/ml STK33 in 10 mM Tris, pH 7.4, 5 mM MgCl₂, 0.5 mM EDTA, 0.5 mM DTT, 5 uM ATP, and 400 ug/ml MBP substrate for 1 hr. at room temperature. Avoid freeze/thaw cycles.
GenBank	NM_030906.2
Mw(kda)	84 kDa

Uniprot	Q9BYT3

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Mujica, A.O., et al., 2001. Gene 280:175-181. 2. Brauksiepe, B., et al., 2008. Biochemistry 9:25-37.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200167	40093	10 ug	$390.50		Add to Cart

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