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Home / Proteins & Peptide

STK3(MST2), GST-tag

SKU : BHP18200134

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Mfr.No.	40013
Description	Human STK3 (serine/threonine kinase 3), also known as MST-2 (Mammalian STE20-like protein kinase 2) or KRS1, GenBank Accession No. NM_006281, a.a. 2-492(end), with N-terminal GST-tag, MW=78.4 kDa, expressed in Sf9 insect cells via a baculovirus expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: 31 pmole/min/ug
Background	STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs. STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand. STK3 activation presumably allows cells to resist unfavorable environmental conditions.
Immunogen Region	2-492(end)
Tag	N-terminal GST-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 18 mM glutathione, and 10% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH 7.5), 10 mM MgCl₂, 1 mM EGTA, 200 uM ATP, 0.01% Brij-35 and 2 uM substrate (Ser/Thr Peptide 7, Invitrogen) at 30°C for 1 hour. Avoid freeze/thaw cycles.
GenBank	NM_006281
Mw(kda)	78.4 kDa

Synonyms	KRS1; MST2; FLJ90748
Uniprot	Q13188

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Taylor, L.K., et al. (1996). Proc. Natl. Acad. Sci. USA. 93(19):10099-104. 2. Song, H., et al. (2010). Proc. Natl. Acad. Sci. USA. 107(4):1431-6. 3. Kim, D., et al. (2010). PLoS One 5(3):e9616.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200134	40013	10 ug	$390.50		Add to Cart

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