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Home / Proteins & Peptide

Spike Trimer (S1+S2) (B.1.351 Variant, delta242-244) (SARS-CoV-2)

SKU : BHP18201036

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BPS Bioscience

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Mfr.No.	101091
Description	Recombinant SARS-CoV-2 Spike protein in its homotrimeric form, containing S1+S2 subunits and encompassing amino acids 16-1213. This protein corresponds to SARS-CoV-2 Variant B.1.351, also known as variant Beta originally discovered in South Africa, and contains the nine known mutations listed below, in addition to deletion 242-244. It also contains mutations 682RRAR685>A, K986P and V987P. The construct has a C-terminal His-tag (6xHis). Note that the expected MW of the S1+S2 monomer is 137kDa but migrates at a higher MW in SDS-PAGE due to glycosylation. The recombinant protein was affinity purified. *Deletion 242-244 is known as 241-243 in some databases and on the CDC website. This is the same deletion. As stated by Tegally et al., Nature 2021: "We also observe a deletion of three amino acids at positions 242 to 244, which was seen in samples extracted and generated in different laboratories across the NGS-SA. This region is difficult to align; the deletion could potentially also be located at positions 241 to 243, but the resulting sequence would be exactly the same. " Constructs: Spike Trimer (S1+S2) (B.1.351 Variant, 242-244) (16-1213-His) (SARS-CoV-2)
Immunogen Region	16-1213
Tag	C-terminal His-tag
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 20% glycerol
Mutation	L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, A701V, delta242-244
Species	SARS-CoV-2
Notes	Avoid freeze/thaw cycles.
GenBank	MN908947
Mw(kda)	137 kDa + glycans

Synonyms	coronavirus, covid, covid-19, covid19, Sars-cov-2 B1351, 20H/501Y.V2, sars cov 2 Spike Trimer, sarscov2, South African Variant, B1351 mutation, South Africa coronavirus, SARS-CoV-2 S. African, beta, beta, deletion 242-244, deletion 241-243
Uniprot	P0DTC2

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=90%
Storage	At least 6 months at -80°C.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201036	101091	100 ug	$352		Add to Cart

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