SOS1 is a guanine nucleotide exchange factor (GEF) for RAS proteins, which are membrane associated proteins involved in various signaling pathways. RAS proteins are activated by GEF-facilitated GDP exchange for GTP, and inactivated by GTP hydrolysis. RAS signaling is upregulated in many different cancers, thus making RAS activation via SOS1 interaction a promising target for cancer therapy.
Product Type
Recombinant Proteins
Tag
His-Avi
Field of Use
Drug Targets
Molecular Weight
62.4 kDa
Species
Human
Application
ELISA, Western Blot, Inhibitor Screening, Binding Assay, Protein Array.
Expression Source
E. coli
Protein Length
485 aa
Uniprot
Q07889
Shipping
Dry Ice
Purity
>95%, SDS-PAGE
Storage
Stable for 12 months at -80°C, Avoid freeze/thaw cycles