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Home / Proteins & Peptide

SHP-2 (PTPN11), GST-tag

SKU : BHP18200034

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Mfr.No.	30022
Description	Protein tyrosine phosphatase SHP-2, also known as PTPN11 (GenBank accession number NM_002834), a.a. 224-529 (catalytic domain) with N-terminal GST-tag, MW=62 kDa, expressed in an E. coli expression system. Specific activity: >1,000 pmol/min/ug
Background	Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Immunogen Region	224-529
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. Avoid freeze/thaw cycles.
GenBank	NM_002834
Mw(kda)	62 kDa

Synonyms	SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433
Uniprot	Q06124

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. B.G. Neel et al. Trends Biochem. Sci. (2003) 28:284. 2. J.V. Ravetch and L.L. Lanier Science (2000) 290:84. 3. S. Yamazaki et al. J. Infect. Dis. (2003) 187:334.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200034	30022	50 ug was 20 ug	$357.50		Add to Cart

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